Whether using this tool makes sense at all depends on your risk profile and risk aversion. A single user sitting in front of their own PC who wouldn't even dream of ever inserting an unknown USB stick into one of the USB ports (I admit I've done that on occasion

USBGuard is in the repos and apparently there's also a Qt-based GUI for the CLI version though I have not checked this. Good write-ups about how to use the tool are easy to find with Google.